Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies
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چکیده
منابع مشابه
Identification of blocker binding site in mouse TRESK by molecular modeling and mutational studies.
TWIK (tandem-pore domain weak inward rectifying K(+))-related spinal cord K(+) channel, TRESK, a member of the tandem-pore domain K(+) channel family, is the most recently cloned K(2P) channel. TRESK is highly expressed in dorsal root ganglion neuron, a pain sensing neuron, which is a target for analgesics. In this study, a reliable 3D structure for transmembrane (TM) region of mouse TRESK (mTR...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Biomembranes
سال: 2013
ISSN: 0005-2736
DOI: 10.1016/j.bbamem.2012.11.021